Derivative chromosome 9 deletion status key prognostic factor for CML.

2003 JUN 23 - (NewsRx.com & NewsRx.net) -- Derivative chromosome 9 deletion status is the key prognostic factor.

"The BCR-ABL fusion in chronic myeloid leukaemia (CML) is generated by the Philadelphia (Ph) translocation t(9;22) or, in 10% of patients, variants thereof (vPh)," scientists in England report.

"Deletion encompassing the reciprocal product (ABL-BCR) from the derivative chromosome 9 [der(9)] occurs in 15% of all patients, but with greater frequency in vPh patients," wrote A.G. Reid and colleagues, Royal Free & University College, School of Medicine.

"Reports of physical separation of ABL-BCR in non-deleted patients, as well as evolution …